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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of retinoblastoma (RB)
ncRNA name hsa-miR-18a
ncRNA Category miRNA
Disease name retinoblastoma (RB)
Species Homo sapiens
Tissues/Cell_line RB cell lines Y79, RBL30 and RB355
Methods qPCR, Western blot, immunofluorescence staining, cell viability assay, BrdU incorporation assay, CAM assay, luciferase reporter assay
Expression pattern associated
Functional description TFF1-induced apoptosis is mediated through transcriptional activity of p53 with concurrently downregulated miR-18a expression.
PubMed ID 28481041
Year 2017
Title Reduction of the tumorigenic potential of human retinoblastoma cell lines by TFF1 overexpression involves p53/caspase signaling and miR-18a regulation.
Drug-related ncRNA NO

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